Unfolding and aggregation during the thermal denaturation of streptokinase

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Unfolding and aggregation during the thermal denaturation of streptokinase.

The thermal denaturation of streptokinase from Streptococcus equisimilis (SK) together with that of a set of fragments encompassing each of its three domains has been investigated using differential scanning calorimetry (DSC). Analysis of the effects of pH, sample concentration and heating rates on the DSC thermograms has allowed us to find conditions where thermal unfolding occurs unequivocall...

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ژورنال

عنوان ژورنال: European Journal of Biochemistry

سال: 2002

ISSN: 0014-2956

DOI: 10.1046/j.1432-1033.2002.03107.x